Proinflammatory IgG Fc structures in patients with severe COVID-19.
Identifieur interne : 000039 ( Main/Exploration ); précédent : 000038; suivant : 000040Proinflammatory IgG Fc structures in patients with severe COVID-19.
Auteurs : Saborni Chakraborty [États-Unis] ; Joseph Gonzalez [États-Unis] ; Karlie Edwards [États-Unis] ; Vamsee Mallajosyula [États-Unis] ; Anthony S. Buzzanco [États-Unis] ; Robert Sherwood [États-Unis] ; Cindy Buffone [États-Unis] ; Nimish Kathale [États-Unis] ; Susan Providenza [États-Unis] ; Markus M. Xie [États-Unis] ; Jason R. Andrews [États-Unis] ; Catherine A. Blish [États-Unis] ; Upinder Singh [États-Unis] ; Haley Dugan [États-Unis] ; Patrick C. Wilson [États-Unis] ; Tho D. Pham [États-Unis] ; Scott D. Boyd [États-Unis] ; Kari C. Nadeau [États-Unis] ; Benjamin A. Pinsky [États-Unis] ; Sheng Zhang [États-Unis] ; Matthew J. Memoli [États-Unis] ; Jeffery K. Taubenberger [États-Unis] ; Tasha Morales [États-Unis] ; Jeffrey M. Schapiro [États-Unis] ; Gene S. Tan [États-Unis] ; Prasanna Jagannathan [États-Unis] ; Taia T. Wang [États-Unis]Source :
- Nature immunology [ 1529-2916 ] ; 2021.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Cytokines (immunologie), Cytokines (métabolisme), Enfant (MeSH), Facteur de nécrose tumorale alpha (immunologie), Facteur de nécrose tumorale alpha (métabolisme), Femelle (MeSH), Glycosylation (MeSH), Humains (MeSH), Immunoglobuline G (immunologie), Immunoglobuline G (métabolisme), Indice de gravité de la maladie (MeSH), Interleukine-6 (MeSH), Mâle (MeSH), Récepteurs du fragment Fc des IgG (immunologie), Récepteurs du fragment Fc des IgG (métabolisme), Sujet âgé (MeSH).
- MESH :
- immunologie : Cytokines, Facteur de nécrose tumorale alpha, Immunoglobuline G, Récepteurs du fragment Fc des IgG.
- métabolisme : Cytokines, Facteur de nécrose tumorale alpha, Immunoglobuline G, Récepteurs du fragment Fc des IgG.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Femelle, Glycosylation, Humains, Indice de gravité de la maladie, Interleukine-6, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), COVID-19 (immunology), COVID-19 (metabolism), COVID-19 (virology), Child (MeSH), Cytokines (immunology), Cytokines (metabolism), Female (MeSH), Glycosylation (MeSH), Humans (MeSH), Immunoglobulin G (immunology), Immunoglobulin G (metabolism), Interleukin-6 (MeSH), Male (MeSH), Middle Aged (MeSH), Receptors, IgG (immunology), Receptors, IgG (metabolism), SARS-CoV-2 (immunology), SARS-CoV-2 (metabolism), SARS-CoV-2 (physiology), Severity of Illness Index (MeSH), Tumor Necrosis Factor-alpha (immunology), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , immunology : Cytokines, Immunoglobulin G, Receptors, IgG, Tumor Necrosis Factor-alpha.
- immunology : COVID-19, SARS-CoV-2.
- metabolism : COVID-19, Cytokines, Immunoglobulin G, Receptors, IgG, SARS-CoV-2, Tumor Necrosis Factor-alpha.
- physiology : SARS-CoV-2.
- virology : COVID-19.
- Adolescent, Adult, Aged, Child, Female, Glycosylation, Humans, Interleukin-6, Male, Middle Aged, Severity of Illness Index.
Abstract
Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
DOI: 10.1038/s41590-020-00828-7
PubMed: 33169014
Affiliations:
- États-Unis
- Californie, Illinois, Maryland, État de New York
- Chicago, Ithaca (New York), Stanford (Californie)
- Université Cornell, Université Stanford, Université de Chicago
Links toward previous steps (curation, corpus...)
Le document en format XML
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation>
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<author><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
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<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Sheng" sort="Zhang, Sheng" uniqKey="Zhang S" first="Sheng" last="Zhang">Sheng Zhang</name>
<affiliation wicri:level="4"><nlm:affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Ithaca (New York)</settlement>
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<author><name sortKey="Memoli, Matthew J" sort="Memoli, Matthew J" uniqKey="Memoli M" first="Matthew J" last="Memoli">Matthew J. Memoli</name>
<affiliation wicri:level="2"><nlm:affiliation>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
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<author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name>
<affiliation wicri:level="2"><nlm:affiliation>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morales, Tasha" sort="Morales, Tasha" uniqKey="Morales T" first="Tasha" last="Morales">Tasha Morales</name>
<affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schapiro, Jeffrey M" sort="Schapiro, Jeffrey M" uniqKey="Schapiro J" first="Jeffrey M" last="Schapiro">Jeffrey M. Schapiro</name>
<affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tan, Gene S" sort="Tan, Gene S" uniqKey="Tan G" first="Gene S" last="Tan">Gene S. Tan</name>
<affiliation wicri:level="2"><nlm:affiliation>J. Craig Venter Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>J. Craig Venter Institute, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Infectious Diseases, University of California, San Diego, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA. taiawang@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA. taiawang@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA. taiawang@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2021">2021</date>
<idno type="RBID">pubmed:33169014</idno>
<idno type="pmid">33169014</idno>
<idno type="doi">10.1038/s41590-020-00828-7</idno>
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<idno type="wicri:Area/Main/Exploration">000177</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Proinflammatory IgG Fc structures in patients with severe COVID-19.</title>
<author><name sortKey="Chakraborty, Saborni" sort="Chakraborty, Saborni" uniqKey="Chakraborty S" first="Saborni" last="Chakraborty">Saborni Chakraborty</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Joseph" sort="Gonzalez, Joseph" uniqKey="Gonzalez J" first="Joseph" last="Gonzalez">Joseph Gonzalez</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Edwards, Karlie" sort="Edwards, Karlie" uniqKey="Edwards K" first="Karlie" last="Edwards">Karlie Edwards</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Mallajosyula, Vamsee" sort="Mallajosyula, Vamsee" uniqKey="Mallajosyula V" first="Vamsee" last="Mallajosyula">Vamsee Mallajosyula</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buzzanco, Anthony S" sort="Buzzanco, Anthony S" uniqKey="Buzzanco A" first="Anthony S" last="Buzzanco">Anthony S. Buzzanco</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Sherwood, Robert" sort="Sherwood, Robert" uniqKey="Sherwood R" first="Robert" last="Sherwood">Robert Sherwood</name>
<affiliation wicri:level="4"><nlm:affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Ithaca (New York)</settlement>
</placeName>
<orgName type="university">Université Cornell</orgName>
</affiliation>
</author>
<author><name sortKey="Buffone, Cindy" sort="Buffone, Cindy" uniqKey="Buffone C" first="Cindy" last="Buffone">Cindy Buffone</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Kathale, Nimish" sort="Kathale, Nimish" uniqKey="Kathale N" first="Nimish" last="Kathale">Nimish Kathale</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Providenza, Susan" sort="Providenza, Susan" uniqKey="Providenza S" first="Susan" last="Providenza">Susan Providenza</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Xie, Markus M" sort="Xie, Markus M" uniqKey="Xie M" first="Markus M" last="Xie">Markus M. Xie</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Andrews, Jason R" sort="Andrews, Jason R" uniqKey="Andrews J" first="Jason R" last="Andrews">Jason R. Andrews</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singh, Upinder" sort="Singh, Upinder" uniqKey="Singh U" first="Upinder" last="Singh">Upinder Singh</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Dugan, Haley" sort="Dugan, Haley" uniqKey="Dugan H" first="Haley" last="Dugan">Haley Dugan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
<settlement type="city">Chicago</settlement>
</placeName>
<orgName type="university">Université de Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C" last="Wilson">Patrick C. Wilson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
<settlement type="city">Chicago</settlement>
</placeName>
<orgName type="university">Université de Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name>
<affiliation wicri:level="2"><nlm:affiliation>Stanford Blood Center, Palo Alto, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford Blood Center, Palo Alto, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name>
<affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Sheng" sort="Zhang, Sheng" uniqKey="Zhang S" first="Sheng" last="Zhang">Sheng Zhang</name>
<affiliation wicri:level="4"><nlm:affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">Ithaca (New York)</settlement>
</placeName>
<orgName type="university">Université Cornell</orgName>
</affiliation>
</author>
<author><name sortKey="Memoli, Matthew J" sort="Memoli, Matthew J" uniqKey="Memoli M" first="Matthew J" last="Memoli">Matthew J. Memoli</name>
<affiliation wicri:level="2"><nlm:affiliation>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name>
<affiliation wicri:level="2"><nlm:affiliation>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morales, Tasha" sort="Morales, Tasha" uniqKey="Morales T" first="Tasha" last="Morales">Tasha Morales</name>
<affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schapiro, Jeffrey M" sort="Schapiro, Jeffrey M" uniqKey="Schapiro J" first="Jeffrey M" last="Schapiro">Jeffrey M. Schapiro</name>
<affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tan, Gene S" sort="Tan, Gene S" uniqKey="Tan G" first="Gene S" last="Tan">Gene S. Tan</name>
<affiliation wicri:level="2"><nlm:affiliation>J. Craig Venter Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>J. Craig Venter Institute, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Infectious Diseases, University of California, San Diego, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA. taiawang@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA. taiawang@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA. taiawang@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature immunology</title>
<idno type="eISSN">1529-2916</idno>
<imprint><date when="2021" type="published">2021</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>COVID-19 (immunology)</term>
<term>COVID-19 (metabolism)</term>
<term>COVID-19 (virology)</term>
<term>Child (MeSH)</term>
<term>Cytokines (immunology)</term>
<term>Cytokines (metabolism)</term>
<term>Female (MeSH)</term>
<term>Glycosylation (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunoglobulin G (immunology)</term>
<term>Immunoglobulin G (metabolism)</term>
<term>Interleukin-6 (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Receptors, IgG (immunology)</term>
<term>Receptors, IgG (metabolism)</term>
<term>SARS-CoV-2 (immunology)</term>
<term>SARS-CoV-2 (metabolism)</term>
<term>SARS-CoV-2 (physiology)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Tumor Necrosis Factor-alpha (immunology)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Cytokines (immunologie)</term>
<term>Cytokines (métabolisme)</term>
<term>Enfant (MeSH)</term>
<term>Facteur de nécrose tumorale alpha (immunologie)</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Femelle (MeSH)</term>
<term>Glycosylation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunoglobuline G (immunologie)</term>
<term>Immunoglobuline G (métabolisme)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Interleukine-6 (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Récepteurs du fragment Fc des IgG (immunologie)</term>
<term>Récepteurs du fragment Fc des IgG (métabolisme)</term>
<term>Sujet âgé (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term>
<term>Immunoglobulin G</term>
<term>Receptors, IgG</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cytokines</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Immunoglobuline G</term>
<term>Récepteurs du fragment Fc des IgG</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>COVID-19</term>
<term>SARS-CoV-2</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>COVID-19</term>
<term>Cytokines</term>
<term>Immunoglobulin G</term>
<term>Receptors, IgG</term>
<term>SARS-CoV-2</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Immunoglobuline G</term>
<term>Récepteurs du fragment Fc des IgG</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS-CoV-2</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Child</term>
<term>Female</term>
<term>Glycosylation</term>
<term>Humans</term>
<term>Interleukin-6</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Glycosylation</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Interleukine-6</term>
<term>Mâle</term>
<term>Sujet âgé</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33169014</PMID>
<DateCompleted><Year>2021</Year>
<Month>01</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>27</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1529-2916</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>1</Issue>
<PubDate><Year>2021</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>Nature immunology</Title>
<ISOAbbreviation>Nat Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>Proinflammatory IgG Fc structures in patients with severe COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>67-73</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41590-020-00828-7</ELocationID>
<Abstract><AbstractText>Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chakraborty</LastName>
<ForeName>Saborni</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0003-0502-3757</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gonzalez</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Edwards</LastName>
<ForeName>Karlie</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mallajosyula</LastName>
<ForeName>Vamsee</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buzzanco</LastName>
<ForeName>Anthony S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sherwood</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buffone</LastName>
<ForeName>Cindy</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kathale</LastName>
<ForeName>Nimish</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Providenza</LastName>
<ForeName>Susan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Markus M</ForeName>
<Initials>MM</Initials>
<Identifier Source="ORCID">0000-0003-1350-7364</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andrews</LastName>
<ForeName>Jason R</ForeName>
<Initials>JR</Initials>
<Identifier Source="ORCID">0000-0002-5967-251X</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blish</LastName>
<ForeName>Catherine A</ForeName>
<Initials>CA</Initials>
<Identifier Source="ORCID">0000-0001-6946-7627</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Singh</LastName>
<ForeName>Upinder</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dugan</LastName>
<ForeName>Haley</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wilson</LastName>
<ForeName>Patrick C</ForeName>
<Initials>PC</Initials>
<Identifier Source="ORCID">0000-0002-3537-1245</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pham</LastName>
<ForeName>Tho D</ForeName>
<Initials>TD</Initials>
<AffiliationInfo><Affiliation>Stanford Blood Center, Palo Alto, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boyd</LastName>
<ForeName>Scott D</ForeName>
<Initials>SD</Initials>
<Identifier Source="ORCID">0000-0003-0963-044X</Identifier>
<AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nadeau</LastName>
<ForeName>Kari C</ForeName>
<Initials>KC</Initials>
<Identifier Source="ORCID">0000-0002-2146-2955</Identifier>
<AffiliationInfo><Affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pinsky</LastName>
<ForeName>Benjamin A</ForeName>
<Initials>BA</Initials>
<Identifier Source="ORCID">0000-0001-8751-4810</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Sheng</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0001-8206-1007</Identifier>
<AffiliationInfo><Affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Memoli</LastName>
<ForeName>Matthew J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taubenberger</LastName>
<ForeName>Jeffery K</ForeName>
<Initials>JK</Initials>
<Identifier Source="ORCID">0000-0002-9694-7228</Identifier>
<AffiliationInfo><Affiliation>LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morales</LastName>
<ForeName>Tasha</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schapiro</LastName>
<ForeName>Jeffrey M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Gene S</ForeName>
<Initials>GS</Initials>
<AffiliationInfo><Affiliation>J. Craig Venter Institute, La Jolla, CA, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, University of California, San Diego, La Jolla, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jagannathan</LastName>
<ForeName>Prasanna</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Taia T</ForeName>
<Initials>TT</Initials>
<Identifier Source="ORCID">0000-0002-3894-685X</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA. taiawang@stanford.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA. taiawang@stanford.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA. taiawang@stanford.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>U54 CA260517</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01AI139119</GrantID>
<Agency>U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>U19AI111825</GrantID>
<Agency>U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>U54CA260517</GrantID>
<Agency>U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>11</Month>
<Day>09</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Nat Immunol</MedlineTA>
<NlmUniqueID>100941354</NlmUniqueID>
<ISSNLinking>1529-2908</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C496124">FCGR3A protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017452">Receptors, IgG</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="UpdateOf"><RefSource>medRxiv. 2020 May 18;:</RefSource>
<PMID Version="1">32511463</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006031" MajorTopicYN="N">Glycosylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017452" MajorTopicYN="N">Receptors, IgG</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>08</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>10</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>11</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2021</Year>
<Month>1</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>11</Month>
<Day>10</Day>
<Hour>5</Hour>
<Minute>44</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">33169014</ArticleId>
<ArticleId IdType="doi">10.1038/s41590-020-00828-7</ArticleId>
<ArticleId IdType="pii">10.1038/s41590-020-00828-7</ArticleId>
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<region><li>Californie</li>
<li>Illinois</li>
<li>Maryland</li>
<li>État de New York</li>
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<settlement><li>Chicago</li>
<li>Ithaca (New York)</li>
<li>Stanford (Californie)</li>
</settlement>
<orgName><li>Université Cornell</li>
<li>Université Stanford</li>
<li>Université de Chicago</li>
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<name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name>
<name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name>
<name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name>
<name sortKey="Buffone, Cindy" sort="Buffone, Cindy" uniqKey="Buffone C" first="Cindy" last="Buffone">Cindy Buffone</name>
<name sortKey="Buzzanco, Anthony S" sort="Buzzanco, Anthony S" uniqKey="Buzzanco A" first="Anthony S" last="Buzzanco">Anthony S. Buzzanco</name>
<name sortKey="Dugan, Haley" sort="Dugan, Haley" uniqKey="Dugan H" first="Haley" last="Dugan">Haley Dugan</name>
<name sortKey="Edwards, Karlie" sort="Edwards, Karlie" uniqKey="Edwards K" first="Karlie" last="Edwards">Karlie Edwards</name>
<name sortKey="Gonzalez, Joseph" sort="Gonzalez, Joseph" uniqKey="Gonzalez J" first="Joseph" last="Gonzalez">Joseph Gonzalez</name>
<name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name>
<name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name>
<name sortKey="Kathale, Nimish" sort="Kathale, Nimish" uniqKey="Kathale N" first="Nimish" last="Kathale">Nimish Kathale</name>
<name sortKey="Mallajosyula, Vamsee" sort="Mallajosyula, Vamsee" uniqKey="Mallajosyula V" first="Vamsee" last="Mallajosyula">Vamsee Mallajosyula</name>
<name sortKey="Memoli, Matthew J" sort="Memoli, Matthew J" uniqKey="Memoli M" first="Matthew J" last="Memoli">Matthew J. Memoli</name>
<name sortKey="Morales, Tasha" sort="Morales, Tasha" uniqKey="Morales T" first="Tasha" last="Morales">Tasha Morales</name>
<name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name>
<name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name>
<name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name>
<name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name>
<name sortKey="Providenza, Susan" sort="Providenza, Susan" uniqKey="Providenza S" first="Susan" last="Providenza">Susan Providenza</name>
<name sortKey="Schapiro, Jeffrey M" sort="Schapiro, Jeffrey M" uniqKey="Schapiro J" first="Jeffrey M" last="Schapiro">Jeffrey M. Schapiro</name>
<name sortKey="Sherwood, Robert" sort="Sherwood, Robert" uniqKey="Sherwood R" first="Robert" last="Sherwood">Robert Sherwood</name>
<name sortKey="Singh, Upinder" sort="Singh, Upinder" uniqKey="Singh U" first="Upinder" last="Singh">Upinder Singh</name>
<name sortKey="Singh, Upinder" sort="Singh, Upinder" uniqKey="Singh U" first="Upinder" last="Singh">Upinder Singh</name>
<name sortKey="Tan, Gene S" sort="Tan, Gene S" uniqKey="Tan G" first="Gene S" last="Tan">Gene S. Tan</name>
<name sortKey="Tan, Gene S" sort="Tan, Gene S" uniqKey="Tan G" first="Gene S" last="Tan">Gene S. Tan</name>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name>
<name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name>
<name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name>
<name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name>
<name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C" last="Wilson">Patrick C. Wilson</name>
<name sortKey="Xie, Markus M" sort="Xie, Markus M" uniqKey="Xie M" first="Markus M" last="Xie">Markus M. Xie</name>
<name sortKey="Zhang, Sheng" sort="Zhang, Sheng" uniqKey="Zhang S" first="Sheng" last="Zhang">Sheng Zhang</name>
</country>
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</affiliations>
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